InterConnect E-mail: info interconnect. Living with XXY W. Point Loma Blvd. Do you know of an organization? Living With Living With. Their Web site offers general and condition-specific education resources to help teachers and parents better understand the needs of students who have genetic conditions.
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MedlinePlus Genetics contains information on Klinefelter syndrome. This website is maintained by the National Library of Medicine. NHGRI is part of the National Institutes of Health and supports research on the structure and function of the human genome and its role in health and disease. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them. In-Depth Information Medscape Reference provides information on this topic.
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Have a question? References References. Klinefelter syndrome. Genetics Home Reference. Kirmse B. Chen H. Medscape Reference. Learning about Klinefelter syndrome. National Human Genome Research Institute. Klinefelter Syndrome. National Organization for Rare Disorders.
Do you know of a review article? Share this content:. Close Copy Link. You May Be Interested In. How to Find a Disease Specialist. Tips for the Undiagnosed. Support for Patients and Families. Tips for Finding Financial Aid. KS males may experience some of the following learning and language-related challenges: 9 A delay in learning to talk. Infants with KS tend to make only a few different vocal sounds. As they grow older, they may have difficulty saying words clearly. It might be hard for them to distinguish differences between similar sounds.
Trouble using language to express their thoughts and needs. Boys with KS might have problems putting their thoughts, ideas, and emotions into words. Some may find it hard to learn and remember some words, such as the names of common objects. Trouble processing what they hear. Although most boys with KS can understand what is being said to them, they might take longer to process multiple or complex sentences.
In some cases, they might fidget or "tune out" because they take longer to process the information. It might also be difficult for KS males to concentrate in noisy settings. They might also be less able to understand a speaker's feelings from just speech alone.
Reading difficulties. Many boys with KS have difficulty understanding what they read called poor reading comprehension. They might also read more slowly than other boys. Social and Behavioral Symptoms Many of the social and behavioral symptoms in KS may result from the language and learning difficulties. Boys with KS, compared to typically developing boys, tend to be: Quieter Less assertive or self-confident More anxious or restless Less physically active More helpful and eager to please More obedient or more ready to follow directions In the teenage years, boys with KS may feel their differences more strongly.
Some common additional symptoms for several poly-X Klinefelter syndromes are listed below. Prenatal Diagnosis , 17 4 , Visootsak, J. Klinefelter syndrome and its variants: An update and review for the primary pediatrician. Clinical Pediatrics Phila , 40 12 , Simpson, J. Klinefelter syndrome: Expanding the phenotype and identifying new research directions.
Genetics in Medicine , 5 6 , Plotton, I. Males have an X and a Y chromosome written as XY. The two sex chromosomes help a person develop fertility and the sexual characteristics of their gender. In this variation, some of the cells in the male's body have an additional X chromosome, and the rest have the normal XY chromosome count.
The percentage of cells containing the extra chromosome varies from case to case. Klinefelter syndrome is found in about 1 out of every , newborn males. The additional sex chromosome results from a random error during the formation of the egg or sperm. About half of the time the error occurs in the formation of sperm, while the remainder are due to errors in egg development.
Women who have pregnancies after age 35 have a slightly increased chance of having a boy with this syndrome. Males who have Klinefelter syndrome may have the following symptoms: small, firm testes, a small penis, sparse pubic, armpit and facial hair, enlarged breasts called gynecomastia , tall stature, and abnormal body proportions long legs, short trunk.
School-age children may be diagnosed if they are referred to a doctor to evaluate learning disabilities. The diagnosis may also be considered in the adolescent male when puberty is not progressing as expected. Adult males may come to the doctor because of infertility.
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